CAY-1, a fungicidal saponin fromCapsicumsp. fruit

Synergism of CAY-1 with amphotericin B and itraconazole.

BACKGROUND CAY-1 is a fungicidal saponin from cayenne pepper whose mode of action differs from amphotericin B (AB) and itraconazole (IT). This work determined CAY-1 synergism with AB or IT. METHODS CAY-1 was purified and used in checkerboard microdilution studies where CAY-1 and AB or IT were mixed with nongerminated (NG) and germinating (G) conidia of three Aspergillus species and Candida al...

Fungicidal activity of cecropin A.

Cecropin A (CA) fungicidal properties were explored. Nongerminated and germinated Aspergillus spp. and Fusarium spp. conidia were treated with CA. CA achieved complete lethality at < or = 25 microM (99 micrograms/ml) for germinating, but not nongerminating, conidia of Aspergillus spp. CA achieved total lethality for nongerminated and germinating conidia of Fusarium spp at 1.5 microM (6 microgra...

Pharmacological activities of saponin-containing fraction derived from Gleditsia caspica Desf. methanolic fruit extract

Phytochemical investigations of Gleditsia fruits have revealed the presence of triterpenoidal saponins. These saponins proved to possess anti-inflammatory and anti-allergic activities. The present study was undertaken to evaluate the anti-inflammatory, analgesic and antipyretic activities of the saponin fraction derived from the methanolic extract of Gleditsia caspica fruits. The fraction at 31...

New analogues of the potent cytotoxic saponin OSW-1.

Saponin OSW-1 (5e-G2; 3 beta,16 beta,17 alpha-trihydroxycholest-5-en-22-one 16-O-{O-[2-O-(4-methoxybenzoyl)-beta-D-xylopyranosyl]-(1-->3)-2-O-acetyl-alpha-arabinopyranoside}) analogues: with modified side chain (5a/d-G2), 22-deoxo-23,24,25,26,27-pentanor- (14), 22-deoxo-23-oxa- (17), glycosylated with various monosaccharides (5e-G4/G6/G8), and OSW-1 structural isomer (10) were obtained. The ana...

M ar 1 99 8 THERMODYNAMIC VARIABLES FROM SPECTATOR DE - CAY ∗